Summary statistics for the fixed effects Meta-analysis of the genome-wide association study of Ewing Sarcoma (Hubbard et al., Cell Genomics 2026)

Genome-wide association study (GWAS) meta-analysis summary statistics for Ewing sarcoma (EwS) susceptibility, from Hubbard et al., “Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk,” Cell Genomics (2026). https://doi.org/10.1016/j.xgen.2026.101422 Contents: fixed-effects meta-analysis results (Metasoft) from six independent case–control analytic sets (eight studies): 1,727 EwS cases and 9,952 cancer-free controls with at least 80% genetic similarity to European reference samples. The GMKF case–parent trios and cases of other genetic ancestries are not included. Methods summary: genotypes were imputed to the TOPMed r3 reference panel (CESS was imputed to 1000 Genomes phase 3), except SJLIFE, which used whole-genome sequencing. See paper in Cell Genomics for full case-control study inclusion. Logistic regression under an additive model was run in PLINK 1.9 (SNPTEST v2 for CESS), adjusting for study-specific principal components. Results were combined by fixed-effects meta-analysis in Metasoft. Filters: variants with minor allele frequency < 0.01, Hardy-Weinberg P < 1×10⁻⁶ in controls, or imputation quality < 0.3 were removed before meta-analysis. Variants with heterogeneity across studies (Cochran’s Q P < 0.05) were excluded from this file. Format: positions are on GRCh38. Effects are reported for the effect allele (A1) relative to the reference allele (A2). Full column definitions and methods are in the accompanying README. Citation and contact: please cite the article above when using these data. Questions: Aubrey K. Hubbard ([e-mail]); Mitchell J. Machiela ([e-mail]).