Konrath2020_p53_signaling_model

The ODE model is based on Batchelor et al., Mol. Syst. Biol. 7 (2011) and was extended by introducing explicit descriptions of the transcription and translation processes of Mdm2 mRNA and Wip1 mRNA. To capture the heterogeneous single cell dynamics of p53 with an ODE model, we clustered the time courses measured by single cell time lapse microscopy into ten subpopulations and created subpopulation models (labelled "a" to "j"). By fitting the subpopulation models to the clustered time course data, we developed to our knowledge the first quantitative p53 model reproducing heterogeneous dynamics of p53.