Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration

1) We analyzed the impact of vitamind D3 (cholecalciferol) treatment on transcriptional signatures of bone marrow derived macrophages 2) Moreover, we analyzed cell populations infiltrating human split-thickness skin grafts (STSG) that had been subcutaneously implanted into wild-type mice (C57BL6/J). Overall design: scRNA-seq was performed on: 1) cultured murine bone marrow derived macrophages with or without treatment with vitamind D3 for 24 h and 2) human split-thickness skin grafts that had been subcutaneously implanted into wild-type (C57BL6/J) mice for 14 days, n=5 mice