Expression data from mouse spleens after experimental stroke (reanalysis of dataset GSE70841 with additional experimental)

Infection is a major complication and cause of mortality and morbidity after acute stroke however the mechanisms are poorly understood. After experimental stroke the microarchitecture and cellular composition of the spleen are extensively disrupted resulting in deficits to immune function. We used microarray to determine differentially expressed genes in the spleens of mice after experimental stroke to determine contributers to immunosuppression after stroke. We extracted RNA from spleens from mice 1d (n=3), 2d (n=3) and 5 d (n=4) after experimental stroke and also from spleens from sham-operated control mice (n=2) for comparison.