Characteristics of Mice Infused with AngII alone or both AngII and PD123319.

Body weights and plasma cholesterol concentrations were determined at termination. Systolic blood pressures were recorded during the last week of the study. Aortic rupture was confirmed by necropsy with visible blood clot in the abdominal cavity and verification of disrupted aortic structure of abdominal aorta. Values are represented as mean±SEM. Two way ANOVA was performed for body weights and plasma cholesterol concentrations, two way repeated measures ANOVA was used to analyze systolic BP data, and Fisher's exact test was done for aortic rupture rate. There were no significant differences between AT2 receptor genotypes (+/y versus −/y) and between manipulations (AngII versus AngII+PD123319) for all parameters tested in this table.