Cyclobutene Ring-Opening of Bicyclo[4.2.0]octa-1,6-dienes: Access to CF3‑Substituted 5,6,7,8-Tetrahydro-1,7-naphthyridines
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Cyclobutene_Ring_Opening_of_Bicyclo_4_2_0_octa_1_6_dienes_Access_to_CF_sub_3_sub_Substituted_5_6_7_8_Tetrahydro_1_7_naphthyridines/2480614
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资源简介：
An efficient method for the synthesis of novel CF3-substituted tetrahydro-1,7-naphthyridines including cyclic α-amino acid derivatives has been developed. The method is based on unusual cyclobutene ring-opening of bicyclo[4.2.0]octa-1,6-dienes with pyrrolidine to afford the corresponding 1,5-diketones followed by their heterocyclization. A convenient one-pot procedure has been also elaborated starting from readily available trifluoromethylated 1,6-allenynes.
创建时间：
2016-02-20
