Differentiating metabolites (p-value <0.05) among EAC, high-risk (BE and HGD) and control groups.

ap-value determined from Student's t-test, only p-values bFC: fold change between esophageal adenocarcinoma (EAC) and healthy controls. Positive sign indicates a higher level in EAC and a negative value indicates a lower level;cThe structural isomers of leucine and isoleucine could not be separated with the current LC method.