Expression data from Notch intracellular domain overexpressing primary murine liver sinusoidal endothelial cells

Liver sinusoidal endothelial cells (LSEC) constitute discontinuous, permeable microvessels, with a characteristic programme of gene expression that differs significantly from continuous microvascular endothelial cells e.g. in the lung. Notch signalling plays a crucial role in a variety of processes in endothelial cells such as vascular morphogenesis, and vascular differentiation. We used microarrays to analyse the programme of gene expression in murine liver endothelial cells with enhanced Notch signalling. Murine liver sinusoidal endothelial cells (mLSEC) from Notch intracellular domain hepatic endothelial cell specific overexpression mice (NICD-OE-HEC) and control mice were isolated for RNA extraction and hybridization on Affymetrix microarrays.