Transcriptional changes in the Anisakis pegreffii third larval stage during human dendritic cells host-parasite interactions

Anisakiasis is a zoonotic human disease provoked by the accidental ingestion of larvae of anisakid nematodes, so far reported as belonging to the two zoonotic species Anisakis pegreffii and A. simplex (s. s.). In humans, the larvae induced a T-cell-mediated inflammatory response through TH2 differentiation, starting with the recognition of parasitic pathogen by pattern recognition receptors (PRRs) that are expressed on the dendritic cells. They are capable of inhibiting in vitro generated dendritic cells (DCs). The effects of the DCs on transcriptional responses in Anisakis pegreffii larvae are investigated for the first time by high-throughput RNA-sequencing (RNA-seq) technologies.