RNA-Seq Time-Course of Rat Bladder Transcriptomes Following Spinal Cord Injury

Spinal cord injury (SCI) evokes profound dysfunction in hollow organs such as the urinary bladder and gut. Current treatments are limited by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed systemic treatment with the neuroprotective agent inosine improved bladder function following SCI in rats. This RNA-seq dataset captures global transcriptomic changes in the rat bladder at multiple time points following spinal cord injury (SCI). Full-thickness bladder tissues were collected from male Sprague Dawley rats at 2, 8, and 16 weeks post-complete T8 spinal cord transection, alongside non-injured controls.脊髓损伤（Spinal cord injury, SCI）可引发膀胱、肠道等空腔脏器的严重功能障碍。当前治疗手段受限于缺乏可用于指导新型治疗路径的分子生物学数据。此前本团队已证实，使用神经保护剂肌苷进行全身给药，能够改善大鼠脊髓损伤后的膀胱功能。本RNA测序（RNA-seq）数据集捕获了大鼠脊髓损伤后多个时间点下膀胱组织的全局转录组变化。研究人员于完全性T8脊髓横断术后的第2、8、16周，从雄性斯普拉格-道利大鼠（Sprague Dawley rats）体内采集全层膀胱组织，并同步收集未损伤大鼠的对应组织作为对照。