Whole genome sequencing of Enterococcus faecium clinical isolates

Daptomycin (DAP) is a lipopeptide antibiotic with potent bacterial activity against Gram-positive bacteria. However, emergence of daptomycin-nonsusceptible Enterococcus (DNSE) in patients during DAP therapy is critical issue in clinical settings. In this study, whole genome sequence of two E. faecium isolates before and after becoming non susceptible to DAP in single patient was analyzed