Baseline characteristics of included patients.

*These comparisons between HCC cases and controls are statistically significant (Pet al., for the present study both cohorts served as replication cohorts.1Age and sex data was missing in 5 patients in the Bonn/Berlin cohort. For the SCCS, age of infection is shown. Age of infection was unknown for the Bonn/Berlin cohort, for this cohort age at diagnosis is shown.2Alcohol consumption data was missing in 12 HCC and 290 non-HCC patients from the SCCS.3HCV genotype was missing in 5 HCC and 23 non-HCC patients from the SCCS, in 1 HCC and 2 non-HCC patients from the Japanese GWAS, and 50 HCC patients from the Japanese replication cohorts.