Integrated Single-Cell Proteomics Analysis on an Active Matrix Digital Microfluidic Chip

We introduce and implement a comprehensive single-cell proteomics sample pre-treatment solution based on an active matrix digital microfluidics chip(AM-DMF-SCP). This platform accommodates high-throughput single-cell isolation and seamless, non-destructive sample pre-treatment, characterized by its efficiency, speed, stability, and ease of use, thereby overcoming the longstanding bottleneck in single-cell protein sample preparation.

本研究提出并实现了一种基于有源矩阵数字微流控芯片（active matrix digital microfluidics chip，AM-DMF-SCP）的单细胞蛋白质组学样本预处理综合解决方案。该平台可实现高通量单细胞分离与无缝无损的样本预处理流程，兼具高效、快速、稳定且易操作的特性，从而突破了单细胞蛋白质样本制备领域长期存在的核心瓶颈。

搜集汇总

背景与挑战

背景概述

该数据集基于主动矩阵数字微流控芯片（AM-DMF-SCP）提供单细胞蛋白质组学样本预处理解决方案，旨在克服单细胞蛋白质样本制备的瓶颈，具有高效、快速和稳定的特点。数据集包含340.36GB的原始数据文件，涉及多种细胞类型的实验数据，适用于蛋白质组学研究，并采用CC0许可公开共享。