Kinetic parameters of lactate transport via MCT4.

Figshare2015-12-03 更新2026-04-29 收录

乳酸转运动力学

MCT4单羧酸转运蛋白

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*Taken from reference 1.Kinetic parameters of lactate transport via MCT4.

创建时间：

2015-12-03

Discovery of 5‑{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology

肿瘤代谢

MCT4单羧酸转运蛋白

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate tr

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Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit

肿瘤代谢靶点验证

MCT4单羧酸转运蛋白

Lactic acid transport is a key process maintaining glycolytic flux in tumors. Inhibition of this process will result in glycolytic shutdown, impacting on cell growth and survival and thus has been pur

NIAID Data Ecosystem30

Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology

肿瘤药物开发

MCT4单羧酸转运蛋白

Due to increased reliance on glycolysis, which produces lactate, monocarboxylate transporters (MCTs) are often upregulated in cancer. MCT4 is associated with the export of lactic acid from cancer cell

Figshare2022-12-16 更新10

Effect of extracellular pH on kinetic parameters of L-lactate uptake by hMCT4-expressing oocytes.

乳酸转运动力学

细胞外pH效应

Data were taken from Fig. 2.

NIAID Data Ecosystem30

DataSheet_1_Integrative Analysis Identified MCT4 as an Independent Prognostic Factor for Bladder Cancer.docx

癌预后标志物

MCT4单羧酸转运蛋白

BackgroundBladder cancer is the 10th most common cancer and most common urothelial malignancy worldwide. Prognostic biomarkers for bladder cancer patients are required for individualized treatment. Mo

NIAID Data Ecosystem20

Kinetic parameters of lactate transport via MCT4.

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