In activated B cells, activation-induced cytidine deaminase (AID) generates programmed DNA lesions required for antibody class-switch recombination (CSR), which may also threaten genome integrity. AID
The ATR kinase is a master regulator of cellular responses to DNA damage and replication stress that is activated by a complex mechanism involving its binding partner ATRIP, RPA-coated ssDNA, the 9-1-
This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in
