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Clonal tracking in gene therapy patients unraveled a diversity of human hematopoietic differentiation programs

NIAID Data Ecosystem2026-04-25 收录

克隆追踪

造血细胞分化

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP215284 数据链接链接失效反馈

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资源简介：

Clonal tracking in gene therapy patients unraveled a diversity of human hematopoietic differentiation programs.

应用场景：

创建时间：

2019-07-19

造血细胞分化

转录调控机制

The specification of hematopoietic cells in the developing embryo occurs in specific stages and is regulated by the successive establishment of specific transcriptional networks. However, the molecula

NIAID Data Ecosystem50

The mediator subunit Med23 serves as a gatekeeper of the myeloid-primed state of hematopoietic stem cells (RNA-Seq)

造血细胞分化

Med23基因调控

To ensure the rapid response to stimuli, some HSCs are specifically prepared (primed) for tasks involving activation and reconstitution. However, the key factors that regulate the primed state of HSCs

NIAID Data Ecosystem40

Myeloid differentiated cells vs hemopoietic progenitors. Homo sapiens

造血细胞分化

转录组差异

Differential gene expression profiling of human hemopoietic progenitors and myeloid differentiated cells Keywords: parallel sample Overall design: We assessed the gene expression in Lin+CD34+, CD14+,

NIAID Data Ecosystem20

Lamin B1 deletion in myeloid neoplasms alters hematopoietic cell fate and causes Pelger-Huët nuclear anomaly. Lamin B1 deletion in myeloid neoplasms alters hematopoietic cell fate and causes Pelger-Huët nuclear anomaly

肿瘤分子机制

造血细胞分化

The most common cytogenetic abnormality found in complex karyotype high risk MDS/AML is del5q. Disease is often identified through visual inspection and recognition of abnormalities such as pseudo-Pel

NIAID Data Ecosystem50

Chromatin architecture landscape in hierarchical hematopoietic cells

染色体三维结构

造血细胞分化

The spatiotemporal chromatin reorganization during hematopoietic differentiation has not been well characterized, which partly limited by the large amounts of starting cells for the current high-throu

NIAID Data Ecosystem30

Clonal tracking in gene therapy patients unraveled a diversity of human hematopoietic differentiation programs

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