Table2_Prediction of Two Molecular Subtypes of Gastric Cancer Based on Immune Signature.xlsx

Gastric cancer is the fifth most common type of human cancer and the third leading cause of cancer-related death. The purpose of this study is to investigate the immune infiltration signatures of gastric cancer and their relation to prognosis. We identified two distinct subtypes of gastric cancer (C1/C2) characterized by different immune infiltration signatures. C1 is featured by immune resting, epithelial–mesenchymal transition, and angiogenesis pathways, while C2 is featured by enrichment of the MYC target, oxidative phosphorylation, and E2F target pathways. The C2 subtype has a better prognosis than the C1 subtype (HR = 0.61, 95% CI: 0.44–0.85; log-rank test, p = 0.0029). The association of C1/C2 with prognosis remained statistically significant (HR = 0.62, 95% CI: 0.44–0.87; p = 0.006) after controlling for age, gender, and stage. The prognosis prediction of C1/C2 was verified in four independent cohorts (including an internal cohort). In summary, our study is helpful for better understanding of the association between immune infiltration and the prognosis of gastric cancer.

胃腺癌是人类最常见的第五种癌症类型，同时也是癌症相关死亡的第三大原因。本研究旨在探究胃腺癌的免疫浸润特征及其与预后的关系。研究团队鉴定出两种具有不同免疫浸润特征的独立亚型（C1/C2）。C1亚型以免疫静息、上皮间质转化和血管生成通路为特征，而C2亚型则以MYC靶点富集、氧化磷酸化和E2F靶点通路为特征。C2亚型的预后优于C1亚型（HR = 0.61，95% CI: 0.44–0.85；log-rank检验，p = 0.0029）。在调整年龄、性别和分期等因素后，C1/C2与预后的相关性依然具有统计学意义（HR = 0.62，95% CI: 0.44–0.87；p = 0.006）。在包括内部队列在内的四个独立队列中验证了C1/C2对预后的预测能力。总之，本研究有助于深入理解免疫浸润与胃腺癌预后之间的关联。