Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.
收藏PubMed Central1994-02-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC43195/
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资源简介：
With T-cell lines constitutively expressing Nef from the SF2 strain of human immunodeficiency virus type 1 (HIV-1SF2) in the form of a hybrid CD8-Nef fusion protein or T-cell lines chronically infected with HIV-1SF2, a cellular serine kinase was found that specifically associates with Nef. Proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, were phosphorylated in in vitro kinase assays. This Nef-associated serine kinase activity was not blocked by inhibitors of protein kinase C or protein kinase A and was lost when Nef was truncated at amino acid 94 or 99. These findings present evidence that a serine kinase activity is associated with Nef expressed in human T lymphocytes. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1994-02-15
