Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE191072
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资源简介：
We revealed that concurrent activation of the Kras and canonical Wnt pathways resulted in formation of ICPN and BilIN, which could develop into biliary cancer. We found that c-Myc contributed to tumorigenesis, whereas Tgf-β pathway inhibited it. Hnf1bCreER, Hnf1bCreER;Kras, Hnf1bCreER;Ctnnb1, and Hnf1bCreER;Kras;Ctnnb spheroids were analyzed (n=3/group).
创建时间：
2022-06-25
