Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase.
收藏PubMed Central1992-07-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC49448/
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资源简介：
The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-07-01
