Inhibiting LCN2 can suppress the development of NSCLC by promoting ferroptosis

Ferroptosis, a recently discovered form of regulated cell death, has been closely linked to tumor progression. However, the underlying mechanism of ferroptosis in non-small cell lung cancer (NSCLC) remains unclear. In this study, we conducted transcriptome sequencing on NSCLC samples. Overall, our study suggests that suppressing LCN2 can effectively inhibit the development of NSCLC by promoting ferroptosis collect tumor and paratumor tissue of 3 NSCLC patients and perform RNA-seq.