OICR: Molecular Pathological Epidemiology of Colorectal Cancer

Colorectal cancer, the second most commonly diagnosed cancer, is a biologically heterogeneous disease. To characterize the molecular attributes of colorectal tumors, we conducted targeted sequencing at the Ontario Cancer Research Institution (OICR) of tumor and matched normal DNA samples from 2,542 colorectal cancer cases in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) [phs001078] and the Colon Cancer Family Registry (CCFR). These consortia are based on cohort and population-based case-control studies.]]> Study participants were unrelated adults with colorectal cancer from the Colorectal Cancer Study of Austria (CORSA), Cancer Prevention Study II (CPSII), Darmkrebs: Chancen der Verhütung durch Screening (DACHS), Ontario Familial Colorectal Cancer Registry (OFCCR), Seattle Colon Cancer Family Registry (SCCFR), and Women's Health Initiative (WHI). Patient inclusion and exclusion criteria reflected those of the individual studies contributing to this project. Additionally, appendix, anal, carcinoid and in situ colorectal tumors were excluded, as were individuals without consent for submitting data to dbGaP and without sufficient samples available for sequencing.]]>