Adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. Adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
Beta-adrenergic stimulation stabilizes ERK3, resulting in the formation of a complex with MK5 and thereby driving lipolysis. A downstream target of the complex is FOXO1, which controls expression of the lipolytic enzyme ATGL. Deletion of ERK3 in mouse adipocytes inhibits lipolysis, but elevates energy dissipation. Overall design: Global gene expression changes in differentiated adipocytes of mice after knockdown of ERK3.
创建时间：
2019-12-20
