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CCL22 mutations in chronic lymphoproliferative disorder of NK cells (CLPD-NK)

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE163864
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We engrafted empty vector, wild type CCL22, and Pro79Arg-CCL22 mutant-expressing NK-92 cells into NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ mice to assess in vivo function of detected CCL22 mutations. Engrafted Pro79Arg NK-92 cells recapitulated the phenotype of CLPD-NK patients with CCL22 mutations. 3 replicates of wild type, empty vector and CCL22-P79R mutant infected NK-92 cell line
创建时间:
2022-04-14
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