Transcriptional Profile of Microglia in Neurodegeneration
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE92550
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Purpose: RNASeq was used to identify transcriptional signature responsible for the metabolic reprogramming phenotype of microglia in neurodegenerative disease Result: We identified Ppargc1a/Cebpb signaling pathway as a critical axis that controls microglial glycolytic transition during neurodegeneration Microglia from the midbrain region of animals with microglial Ppargc1a deficiency or controls were subjected to MPTP injections to induce neurodegeneration or treated with PBS as control. Total RNA from 3 microglia samples from each genotype/condition were isolated and used to prepare RNASeq library and analysis
创建时间：
2020-08-28
