Scalable Synthesis of (−)-Thapsigargin
收藏NIAID Data Ecosystem2026-03-10 收录
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https://figshare.com/articles/dataset/Scalable_Synthesis_of_-Thapsigargin/4480316
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资源简介：
Total syntheses of the complex, highly
oxygenated sesquiterpenes
thapsigargin (1) and nortrilobolide (2)
are presented. Access to analogues of these promising bioactive natural
products has been limited to tedious isolation and semisynthetic efforts.
Elegant prior total syntheses demonstrated the feasibility of creating
these entitites in 36–42 step processes. The currently reported
route proceeds in a scalable and more concise fashion by utilizing
two-phase terpene synthesis logic. Salient features of the work include
application of the classic photosantonin rearrangement and precisely
choreographed installation of the multiple oxygenations present on
the guaianolide skeleton.
创建时间：
2016-12-19
