Attenuated lymphocyte activation leads to the development of immunotolerance on bovine fetuses persistently infected with BVDV

Fetal spleens were collected at days 82 and 97 of gestation following maternal infection with BVDV on day 75 of gestation. A microarray was performed on RNA -> cDNA of the splenic samples. Treatment groups consist of Controls (non-infected) and PI (persistently infected). Day 82 fetuses represent th fetal immune system before BVDV crosses the placenta while day 97 fetuses represent the fetal immune system days after BVDV infects the fetus. Control fetuses were from dams innoculated with MEM media and PI fetuses are from dams innoculated with BVDV on day 75 of gestation. Both day groups have 4 animals in the control treatment group. Day 82 PI n = 3 and day 97 PI n = 4.