Transcriptional adaptation to DNA replication stress induced by CCNE1 overexpression
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE171845
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资源简介：
We overproduced human cyclin E from a stably-integrated inducible CCNE1 transgene in RPE1-hTERT cells over a period of weeks. CCNE1 overproduction induced replication stress, then slow proliferation, followed by adaptation to normal growth phenotype. We analyzed mRNA transcripts at key points of the timecourse: control, 2 days, 15-18 days, 39-51 days, and at a point several weeks after induction was withdrawn Retinal pigmented epithelial (RPE1-hTERT) mRNA profiles of CCNE1 overexpression in adaptation experiment over period of up to 51 days
创建时间：
2022-03-15
