Peptoclostridium difficile Metagenome. Clostridium

Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infections (RCDIs). We characterized bacterial and viral gut microbiota of a cured RCDI patient at different time points up to 4.5 years post-FMT compared to the stool donor. Donor-like bacterial communities in the patient after 4.5 years demonstrated sustainable engraftment of donor feces and verified long-term therapeutic success on the molecular level after a single FMT. Our findings indicate that intestinal viruses may be implicated in the establishment of gut microbiota.