Human Sirt5 in complex with stalled peptidylimidate intermediate of inhibitory compound 29
收藏Protein Data Bank Japan2024-01-17 更新2026-03-21 收录
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Human Sirt5 in complex with stalled peptidylimidate intermediate of inhibitory compound 29 Descriptor: 1,2-ETHANEDIOL, 1,3-BUTANEDIOL, 3-[[(~{Z})-~{C}-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]sulfanyl-~{N}-[(5~{S})-6-[[(2~{S})-3-(1~{H}-indol-3-yl)-1-oxidanylidene-1-(propan-2-ylamino)propan-2-yl]amino]-6-oxidanylidene-5-(phenylmethoxycarbonylamino)hexyl]carbonimidoyl]amino]propanoic acid, ... Authors: Pannek, M, Steegborn, C. Deposit date: 2017-10-15 Release date: 2017-11-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew. Chem. Int. Ed. Engl., 56, 2017
创建时间：
2017-10-15
