Binding of YBX1 to regulatory sequences of MEK/ERK pathway-dependent target genes.

88 genes initially identified in proliferation-associated clusters were recovered as YBX1 targets by ChIP-on-Chip assay. Twenty-six of them (depicted in bold face) were also recognized as YBX1 targets in basal-like breast cancer cells [37]. In contrast, only few of the genes in the proliferation-associated clusters were identified by ChIP-on-Chip assay in HepG2 hepatoma cells (PGRMC1, SLC39A8, RFC3) and in the acute lymphoblastic leukemia line Nalm-6 (RAMP, KIAA0101, PCNA, CENPF) [81], suggesting a specific role of YBX1 in breast and colorectal cells.
* Genes which show a significant positive correlation to YBX1 expression in colorectal cancers.