Table S1 - Is There an Association between Advanced Paternal Age and Endophenotype Deficit Levels in Schizophrenia?

Terms involving paternal age at birth in linear and linear mixed-effects models for endophenotype performance. Abbreviations: CI, confidence interval; CPT-IP, Continuous Performance Test, Identical Pairs version; LNS, Letter-Number Span; CVLT, California Verbal Learning Test. a Only terms involving paternal age at subject birth are reported. b Slope and confidence intervals are in units of a 10-year increase in paternal age at birth. A positive slope indicates that subjects with older fathers perform better on the endophenotype. c P values are based on linear models with effects for paternal age, paternal age–by-gender, and paternal age–by–multiplex status, with subject age, test site, subject gender, and parental education as covariates. d After adjusting for multiple comparisons accounting for the 16 endophenotypes, none of the results are significant at an overall Type I error level of 5%. e P values are based on linear mixed-effects models with effects for paternal age, paternal age–by-gender, and paternal age–by–multiplex status, with group (proband versus sibling), subject age, test site, subject gender, parental education, and all second-order interactions involving group as covariates. Family membership served as a random effect to account for the relatedness of observations among family members. (DOCX)