RNA-Sequencing Characterisation of the Renal Cortical Response to Diet-Induced Weight Loss and Medical Therapy in the Zucker Diabetic Sprague Dawley Rat Model of Diabetic Kidney Disease

We report results from renal cortical transcriptomic analysis of responses to diet-induced weight loss plus medical therapy in the Zucker Diabetic Sprague Dawley (ZDSD) rat model of diabetic kidney disease. Overall design: 3 study groups: Sprague Dawley rats, SHAM-operated Zucker Diabetic Sprague Dawley (ZDSD) rats, and ZDSD rats treated with diet-induced weight loss plus medical therapy (ramipril, metformin, liraglutide, rosuvastatin, fenofibrate).