FHDH
收藏资源简介：
The French Hospital Database on HIV (FHDH) is a hospital-based multicentre open cohort with inclusions ongoing since 1989. The research objectives focus mainly on mid- and long-term clinical outcomes and therapeutic strategies, as well as severe AIDS and non-AIDS morbidities, and public health issues relative to HIV infection. FHDH also serves to describe HIV-infected patients receiving hospital care in France. FHDH includes data on more than 120,000 HIV-infected patients from 70 French general or university hospitals distributed throughout France. Patients are eligible for inclusion if they are infected by HIV-1 or HIV-2 and give their written informed consent. Standardized variables are collected at each outpatient visit or hospital admission during which a new clinical manifestation is diagnosed, a new treatment is prescribed or a change in biological markers is noted, and/or at least every 6 months. Since its inception, variables collected in FHDH include demographic characteristics, HIV-related biological markers, the date and type of AIDS and non AIDS-defining events, antiretroviral treatments and the date and causes of death, as reported in the medical records. Since 2005, data have also been collected on: co-infection with hepatitis B or C virus; alcohol and tobacco use; and non HIV-related biomarkers.
法国HIV医院数据库（French Hospital Database on HIV，缩写FHDH）是一项基于医院的多中心开放队列研究，自1989年起持续招募受试者。其研究目标主要聚焦于中远期临床结局与治疗策略、重症艾滋病（Acquired Immune Deficiency Syndrome，简称AIDS）及非艾滋病相关并发症，同时涵盖与HIV感染相关的公共卫生议题，且用于描述法国境内接受住院治疗的HIV感染患者群体特征。该数据库收录了来自法国全境70家综合医院或大学附属医院的逾12万名HIV感染患者的相关数据。符合纳入标准的患者需满足：感染人类免疫缺陷病毒1型（HIV-1）或人类免疫缺陷病毒2型（HIV-2），且签署书面知情同意书。研究人员会在每次门诊随访或住院期间收集标准化变量，采集时机包括确诊新的临床表现、开具新的治疗方案或检测到生物学标志物变化时，以及至少每6个月一次的常规采集。自数据库创立以来，其收录的变量涵盖人口统计学特征、HIV相关生物学标志物、艾滋病与非艾滋病定义性事件的发生日期及类型、抗逆转录病毒治疗方案，以及病历记录中记载的死亡日期与死亡原因。自2005年起，数据库还新增收录乙型肝炎病毒或丙型肝炎病毒合并感染情况、烟酒使用行为，以及非HIV相关生物学标志物相关数据。
