Prediction of platinum-based neoadjuvant chemotherapy response in muscle-invasive bladder cancer using a multifaceted approach

Dataset

This dataset contains gene-level RNA sequencing count matrices and associated metadata generated from bladder cancer samples analyzed in two experimental phases. The data were produced to investigate transcriptional differences in tumor samples collected during transurethral resection of bladder tumor (TUR-BT) procedures.

Data Contents

The repository includes:

Gene-level count matrix for whole-transcriptome RNA sequencing samples (paired-end sequencing, Discovery phase-1)

Gene-level count matrix for targeted RNA expression sequencing samples (single-end sequencing, Validation phase-2)

Sample metadata describing sample identifiers and experimental groups

All count matrices contain raw read counts and have not been normalized.

Reference Genome and Annotation

Human reference genome: GRCh38 primary assemblyGene annotation: GENCODE release v48

Software

R v.4.4.0

Bioconductor package Rsubread (v2.18.0)

featureCounts (Rsubread)