A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study ofSubcutaneous MOA-728 for the Treatment of Opioid-Induced ConstipationEstudio multicéntrico, aleatorizado, en doble ciego, controlado con placebo y de grupos paralelos, de MOA-728 subcutánea para el tratamiento del e

Primary: To evaluate the safety, efficacy, and tolerability of subcutaneous MOA-728 versus placebo in subjects with nonmalignant pain who have opioid-induced constipation.
Primary endpoints: Two coprimary efficacy endpoints are:1. the proportion of subjects having a RFBM within 4 hours of the first dose administration, and 2. the percentage of injections resulting in any RFBM within 4 hours during the double-blind period.