Gene expression profiles of WT and ime4-/- mutant yeast cells, under vegetative and meiosis-inducing conditions

Inactivation of the yeast IME4 gene, the yeast homologue of METTL3, was shown to result in the loss of m6A in mRNA of mutant cells grown in sporulation medium已有研究证实，对酵母IME4基因——该基因为甲基转移酶样蛋白3（METTL3）的酵母同源物——实施失活处理后，在孢子形成培养基中培养的突变细胞的mRNA会丧失m6A修饰。