Will Hydroxychloroquine Impede or Prevent COVID-19: WHIP COVID-19 Study

This is a prospective, multi-site study designed to evaluate whether the use of
hydroxychloroquine in healthcare workers (HCW), Nursing Home Workers (NHW), first responders
(FR), and Detroit Department of Transportation bus drivers (DDOT) in SE, Michigan, can
prevent the acquisition, symptoms and clinical COVID-19 infection

The primary objective of this study is to determine whether the use of daily or weekly oral
hydroxychloroquine (HCQ) therapy will prevent SARS-CoV-2 infection and COVID-19 viremia and
clinical COVID-19 infection healthcare workers (HCW) and first responders (FR) (EMS, Fire,
Police, bus drivers) in Southeast Michigan.

Preventing COVID-19 transmission to HCW, FR, and Detroit Department of Transportation (DDOT)
bus drivers is a critical step in preserving the health care and first responder force, the
prevention of COVID-19 transmission in health care facilities, with the potential to preserve
thousands of lives in addition to sustaining health care systems and civil services both
nationally and globally. If efficacious, further studies on the use of hydroxychloroquine to
prevent COVID-19 in the general population could be undertaken, with a potential impact on
hundreds of thousands of lives.