Additional file 17 of Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Additional file 17: Table S12. Characterising [AT]n motif expansion in cancer cell lines. A. All MSI DepMap cancer cell lines with WGS data and three MSS DepMap cell lines with WGS data for comparison. Cell_line_stripped_name: cell line names provided by DepMap without special characters or spaces. disease: cancer type assigned by DepMap. MSI_status: inferred microsatellite status by Ghandi et al. (2019). KMT2D_group: KMT2D group assigned to a cell line. SRA_project_ID: NCBI SRA project ID for raw WGS data. SRA_Run_ID: NCBI SRA run ID for raw WGS data. Instrument: sequencer used to perform WGS. B. Profiles of [AT]n motifs generated using ExpansionHunter Denovo. Cell_line_name: cell line names provided by DepMap without special characters or spaces. disease: cancer type assigned by DepMap. SRA_id: NCBI SRAN run ID. group: MSI status and KMT2D group of cell line. Contig: chromosome location of motif. Start: start site (bp) of motif. End: end site (bp) of motif. Motif: motif type. Num_anc_irrs: number of anchored in-repeat reads (i.e. one read pair maps within and the other outside of a repeat region; see Methods). norm_num_anc_irrs: normalised number of anchored in-repeat reads. Het_str_size: estimated motif repeat size.