Statistical analyses of the overlaps between A. ceylanicum genes encoding protein domains (or other traits) and A. ceylanicum genes with either intestine-biased or non-intestine-biased gene expression.

Statistical significances of overlaps between domain/trait genes and intestine-biased or non-intestine-biased genes were computed and described as in S3 Table. In addition, pairwise overlaps between intestine- or non-intestine-biased gene sets and other gene categories are provided in the ‘Various’ spreadsheet; since these do not involve multiple comparisons of entire domain sets, only p-values rather than q-values are computed for these overlaps. A. ceylanicum gene categories in “Various” are: “Intest_haemonchus”, genes with orthology to H. contortus genes with intestine-biased expression; “Non-intest_haemonchus”, genes with orthology to H. contortus genes with non-intestine-biased expression; “WashU-intestine-biased”, genes with intestine-biased expression computed from previously published A. ceylanicum RNA-seq data; “WashU-non-intestine-biased”, genes with non-intestine-biased expression computed from previously published A. ceylanicum RNA-seq data (S11 Table) [67,68]. (XLSX)