Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer [microarray]
收藏NIAID Data Ecosystem2026-05-01 收录
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The gene regulatory network (GRN) underlying CTL differentiation and whether Tex responses can be functionally reinvigorated are incompletely understood. Here, we systematically mapped causal GRNs via single-cell CRISPR (scCRISPR) screens in vivo and discovered checkpoints for CTL differentiation. In total 15 samples were analyzed: sgNTC (4 samples), sgRbpj (4 samples), sgIrf1 (4 samples), sgRbpj + sgIrf1(3 samples),
创建时间：
2023-11-17
