Receptor CXCR6 binds CXCL16 ligand

CXCR6 (formerly called STRL33, BONZO, and TYMSTR) was assigned this name based on its chromosomal location (within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene sequence (Liao F et al, 1997). CXCR6 is structurally more closely related to CC chemokine receptors than to other CXC chemokine receptors. It is expressed in lymphoid tissues and activated T cells and is induced in activated peripheral blood lymphocytes. CXCR6 binds the ligand CXCL16 (Shimaoka T et al, 2000) which acts as a scavenger receptor on macrophages. It specifically binds to oxidized low density lipoprotein, suggesting that it may be involved in pathophysiology such as atherogenesis.

CXCR6（曾命名为STRL33、BONZO和TYMSTR）之命名，源于其染色体定位（位于人类染色体3p21上的趋化因子受体簇）及其基因序列中与其他趋化因子受体的相似性（Liao F 等，1997年）。CXCR6在结构上与CC趋化因子受体关系更为密切，而非其他CXC趋化因子受体。该受体在淋巴组织及活化T细胞中表达，并在活化外周血淋巴细胞中被诱导。CXCR6结合配体CXCL16（Shimaoka T 等，2000年），其在巨噬细胞上作为清道夫受体发挥作用。它特异性地结合氧化低密度脂蛋白，暗示其可能参与诸如动脉粥样硬化等病理生理过程。