Data Underpinning "Coupling Between Cerebral Blood Flow And Cerebral Blood Volume: Contributions Of Different Vascular Compartments"

The data in this archive was acquired to investigate the coupling between cerebral blood flow and cerebral blood volume across different vascular compartments. These results will form the basis of a forthcoming publication. Please reference this dataset if you use it in your work. Wesolowski R, Blockley NP, Driver ID, Francis ST, Gowland PA. Data underpinning "Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments". Zenodo 2018. doi: 10.5281/zenodo.1173621. This dataset contains measurements of the haemodynamic responses of different compartments to a visual stimulus (8Hz red LED goggles, 19.2s ON, 40.8s OFF). Time course data are cycle averaged for the following haemodynamic properties; Arterial cerebral blood volume (CBVa) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBVa. Cerebral blood flow (CBF) measured using Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) sensitised to CBF. Total cerebral blood volume (CBVtot) measured using bolus injections of a Gadolinium based contrast agent combined with T2* weighed gradient echo EPI. In addition, weighted mean and standard deviation of the changes in these parameters are presented using time windows of 9.6–19.2s and 40.8–60s for ON and OFF, respectively. Weighting is performed with respect to the number of voxels present in each of the subjects regions of interest.