Table S1 - FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

After 5 days of acclimatization, the weight-matched animals were assigned to one the following experimental groups (n = 5 per group). a) control ad libitum (CONT), b) 36 hours fasting (FAST 36 h), c) re-feed after 36 hours fasting followed by 15 minutes of feeding (RE-FEED), d) exercise ad libitum with free access to the activity wheel for 1 or 3 weeks (EXER), e) control activity-based anorexia (CABA), and f) ABA as previously described (Routtenberg and Kuznesof 1967; Pardo et al. 2010). Diet-induced obesity (DIO) animals (200 g) were fed with a 60% high fat diet D12492 (Research Diets, NJ) over 9 weeks, and age-matched lean rats were used as a control. Male obese Zucker rats (fa/fa, n = 10) and their control counterparts (CZ), lean Zucker rats (fa/-, n = 10), were purchased from Charles River Laboratories (Barcelona, Spain) at 10 weeks of age and fed chow ad libitum for 12 weeks. (DOCX)