Crystal structure of human BRD9 bromodomain in complex with a PROTAC
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Crystal structure of human BRD9 bromodomain in complex with a PROTAC Descriptor: (2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 9 Authors: Hughes, S.J, Zoppi, V, Ciulli, A. Deposit date: 2018-09-11 Release date: 2019-01-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J.Med.Chem., 62, 2019
创建时间：
2018-09-11
