Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework II
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https://www.ncbi.nlm.nih.gov/sra/SRP435277
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资源简介：
To inhibit JAK2 upon IL-6 and IL-10-induced JAK-STAT signaling and quantify gene expression in bone marrow derived macrophages (BMDMs). Bulk RNAseq was done on cytokine-stimulated BMDM with and without Fedratinib treatment in order to profile the JAK2-inhibited cytokine-induced response. Overall design: We stimulated BMDM with IL-6 and IL-10 at 1 ng/ml at 0, 1 and 2 hours with or without 1 nM of Fedratinib
创建时间：
2023-08-08
