Metabolomics data for: Microbiome study in irradiated mice treated with a promising radiation countermeasure, BIO 300

The mammalian gut harbors a very complex and diverse microbiota that play an important role in the intestinal homeostasis and host health. Exposure to radiation results in dysbiosis of the gut microbiota leading to detrimental pathophysiological changes to the host. To alleviate the effects of irradiation, several candidate countermeasures are under investigation. BIO 300 is a promising candidate under advanced development. The aim of this study was to investigate the effects of BIO 300 on the gut microbiome and metabolome of mice exposed to 60Co gamma-radiation. The gut microbiota and metabolome of control and drug treated mice exposed to irradiation was characterized by bacterial 16S rRNA amplicon sequencing and untargeted metabolomics. We found that irradiation, altered the ratio of Bacteroidetes to Firmicutes as well as significantly decreased the relative abundance of Lactobacillus, initially, both in BIO 300-treated and control mice; however, the ratio returned to near normal leve...