The protein moonlighting dominates the phenotypic divergence of the Sef1 transcriptional regulatory networks in yeasts. The protein moonlighting dominates the phenotypic divergence of the Sef1 transcriptional regulatory networks in yeasts

We report the ChIP-seq profiling of a transcriptional factor Sef1 in Sccharomyces cerevisiae, and show that ScSef1 targets many TCA cycle and many others genes but has very limited regulatory effects to these target genes. Overall design: ScSef1 ChIP-seq analysis was performed from three or four biological replicates of YPD- and YPGly-grown Sef1-TAP tagged cells, using Illumina NextSeq500 sequencer.