Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor LR4-46

Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor LR4-46 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[{4-[(1R)-1-hydroxyethyl]benzene-1-sulfonyl}(2-methylpropyl)amino]butan-2-yl}carbamate, Protease Authors: Kaur, J, Shaqra, A.M, Schiffer, C.A. Deposit date: 2025-08-13 Release date: 2025-12-24 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. Eur.J.Med.Chem., 304, 2025