Transcriptome-wide Analysis of Trigeminal Ganglion and Subnucleus Caudalis in a Mouse Model of Chronic Constriction Injury-induced Trigeminal Neuralgia

This study used a whole-transcriptome sequencing approach to comprehensively examine ncRNA and mRNA expression signatures in the trigeminal ganglion (TG) and trigeminal subnucleus caudalis (Sp5C) of infraorbital nerve chronic constrictive injury (IoN-CCI)-induced TMP mice. Furthermore, bioinformatics analysis was used to interpret the potential biological functions of pain-related differentially expressed (DE) genes, DE ncRNAs and DE mRNAs, and the potential regulatory mechanisms of ncRNAs in TNP.